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When oxidative stress causes excessive generation of oxygen free radicals, keap1 protein releases Nrf2 through the release of zinc ions, followed by the entrance of Nrf2 into the nucleus to bind to the ARE anti-oxidative stress element sequence, and activates gene transcription downstream of the ARE region, which then initiates the oxidative stress response and reduces the oxidative stress

Previous studies have also supported that Grx2 is fundamental for neuronal development

This vaccination-induced activation of both CD4 + and CD8 + T cells and higher splenocyte cytotoxic responses against tumors