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Nrf2, a pivotal transcription factor, plays a critical role in the regulation of oxidative stress

However, in such drugs, the thiol is directly hydroxylated to form sulfenic acid, which is further oxidized to sulfonic acid (Figure 5.17)

Bellia F, Lanza V, Naletova I, Tomasello B, Ciaffaglione V, Greco V, Sciuto S, Amico P, Inturri R, Vaccaro S, Campagna T, Attanasio F, Tabb G, Rizzarelli E (2023) Copper(II) complexes with carnosine conjugates of hyaluronic acids at different dipeptide loading percentages behave as multiple SOD mimics and stimulate Nrf2 translocation and antioxidant response in in vitro inflammatory model

showed that the prevalence of hearing loss was 17.3% and 6.5% in diabetic and non-diabetic patients, respectively ( P 91 dB HL)