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These include larger tumor size, higher tumor grade, and increased lymph node involvement (, )

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2-deoxy-D-glucose (2-DG) is a broad-spectrum glycolysis inhibitor

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This cyclic pathway, catalyzed by NO synthase (NOS), facilitates the continuous conversion of L-arginine to L-citrulline and NO ( Figure 2a ) ( Figure 2e ) ( Figure 2 3.2 Biological basis of multi-organ protective effects The multi-organ protective effects of L-citrulline are principally attributed to its capacity for systemic modulation of NO signaling