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Factors include: pH of gastrointestinal fluids Rate of gastric emptying and intestinal motility Presence or absence of food (which can enhance, delay, or reduce absorption), and Patient's age Disease states such as malabsorption syndromes (e.g., Crohn's disease) or liver disease can also profoundly affect bioavailability

It was first identified in human plasma and has since become a major subject of interest in regenerative biology, tissue engineering, and extracellular matrix research

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Extended use isnt well-studied in humans, so most experts recommend cycling it, typically 48 weeks on, followed by a few weeks off, to support safety and effectiveness.

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