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Ethics approval and consent to participate All animal experiments were undertaken in accordance with the National Institute of Health Guide for the Care and Use of Laboratory Animals, with the approval of the Ethics Committee of the Second Affiliated Hospital, Zhejiang University School of Medicine (Permit number: 2024-260)

N-acetylcysteine can enhance this NO defence[34], but the effect of cystine was unknown

GFP-ASXL1 1-645 -I574D mutant impaired in binding to BRD4, associated with endogenous MLL3 and MLL4 on par with wt GFP-ASXL1 1-645 , indicating that the interactions of ASXL1 with BRD4 and MLL3/4 might be independent

This information informs future cycle planning

Zinc deficiency induces inflammation and apoptosis via oxidative stress in the kidneys of mice