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We identified and clustered four major cell types, including optic neurons, NSPCs, postmitotic neurons, and nonneuronal cells

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For instance, pyrroline-5-carboxylate reductase 1 (PYCR1) triggers H3K18la at the insulin receptor substrate 1 (IRS1) promoter, ultimately promoting liver cancer cell proliferation and lung metastasis

ROS accumulation leads to metabolic abnormalities in RA-FLSs, with decreased mitochondrial oxidative phosphorylation and ATP reserve capacity but increased glycolytic activity in RA-FLSs, promoting RA synovial inflammation (106)

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