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For example, kallikrein and prostaglandin E1 have been proven to significantly improve erectile function in diabetic rats, reduce penile fibrosis, and increase blood perfusion, thereby alleviating microvascular complications and addressing diabetes-related reproductive dysfunction [349, 350]

It drives research towards innovative treatment options and individual therapeutic strategies, aiming at enhancing educational and social interventions for affected individuals

Materials and methods Ethics statement The experimental animals (CBA/J mice) were kept in a standard environment with a temperature of 22 1 C and a relative humidity of 5060%