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Persistent exertional intolerance after COVID-19: insights from invasive cardiopulmonary exercise testing

-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

Complete resolution typically occurs within 2 to 3 weeks

The diversity of the terrain weaknesses at the origin of PAIS development, and the perpetuation mechanisms that are installed are likely to explain the diversity of long-term evolution of these diseases

When insulin signaling is disrupted, these systems can be compromised, allowing the accumulation of toxic proteins aggregates like S and worsening neurodegeneration