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The analysis indicated no significant differences in phase I sleep time between the experimental and control groups (MD = 1.67, 95% CI [1.75, 5.09], p = 0.34), with acceptable heterogeneity ( I 2 = 0%, p = 0.99) (Figure 8)

242 A number of laboratory and animal studies have indicated PQQ can protect nerve cells from toxic and inflammatory damage by reducing oxidative stress and protecting mitochondria

Additional nutritional (vitamin C, N-acetylcysteine, glutathione, etc.) and herbal supplements can improve antioxidant status and decrease chronic inflammation to restore immunological tolerance

doi: 10.3389/fnut.2022.1007816

However, prolonged activation of this axis may contribute to maladaptive changes