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Notably, immune senescence is particularly detrimental to the respiratory system of older adults, who are easy targets for exogenous infections (162)

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Annotated Edition of Dongyi Baojian

However, these in vitro studies often use relatively high Mn concentrations (up to 1 mM), exceeding physiological brain Mn levels, but acute culture systems generally require higher doses to reveal mechanistic effects in the absence of the physiological environment