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Mature or fully differentiated osteoblasts, which express osteocalcin (OCN), acquire functions to mineralize the matrix and produce hardened bone

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Months 3 to 6: Skin thickness and tissue recovery effects, when they appear, settle in around this window

[5] As a treatment, once-daily subcutaneous sermorelin (about 30 g/kg at bedtime) increased height velocity in some prepubertal children with idiopathic growth-hormone deficiency, with responses sustained over roughly 12 months and, in a few children, longer