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Inasmuch as oral glutamate is metabolized rapidly by enterocytes, there was no measurable rise in systemic GABA levels following an oral dose of glutamate (136, 137)

elegans resistance against heat stress showed that the strain B

However, some patients receiving high-dose B12 supplementation or injections may experience adverse reactions, though these relate to the treatment rather than the elevated levels: Possible reactions to B12 supplementation (particularly injections): Skin reactions, including acneiform eruptions or rashes Pruritus (itching) Injection site reactions (with parenteral administration) Rare hypersensitivity reactions Non-specific symptoms such as headaches, dizziness, or gastrointestinal disturbances have been reported by some patients taking B12 supplements, but causality is not well established in clinical evidence

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