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In addition, PFOS can induce autophagy activation with increased Beclin and LC3BII expression through reactive oxygen species (ROS)-mediated extracellular signalregulated kinase (ERK) activation, which is followed by impeded autophagic flux, increased lysosomal membrane permeability (LMP), and, consequently, RTC apoptosis

l-Carnitine and U0126 were obtained from Healthmate (Taichung, Taiwan) and Tocris Cookson (Bristol, UK), respectively

Van Wouwe JP

Our bodies store carnitine in skeletal and cardiac muscle tissues

L-carnitine protects mammalian cells from chromosome aberrations but not from inhibition of cell proliferation induced by hydrogen peroxide