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The residue was purified by flash-column chromatography on silica gel to provide the desired ethyl 4-(adamanthyl-amino)-3-nitrobenzoate derivatives ( a =tert-butyl, MW=372)

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To challenge the hypothesis that multiple tRF-derived sequences could yield informative PD biomarkers, we searched for tRF families that share common sequence motifs whose levels are changed in the brain, blood and/or CSF of patients with PDall biofluids known to reflect cerebral pathologies, including PD 22,37

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doi: 10.7759/CUREUS.22464 156 IranmakaniSMortezazadehTSajadianFGhazianiMFGhafariAKhezerlooDet al