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3.11 Intrachain and interchain disulfide bonds of RBD (319-541)-His6 detected with ESI-MS The RBD (319-541)-His6 monomer contains nine cysteine residues, with eight of them forming four intramolecular disulfide bonds (Supplementary Figure S1B)

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14 Constraints of existing evidence Despite promising preclinical and early clinical findings, several limitations constrain the translation of apigenin and ellagic acid into mainstream PCOS therapy