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Fasting or fasting-mimicking diet In addition to CR, alternative approaches such as intermittent fasting (IF), including short-term fasting (STF), intake of an FMD, and time-restricted feeding (TRF), which limits food consumption to a specific time window each day, are being condisered

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For the young or active adult, this includes activities of daily living as well as recreational and sports participation

doi: 10.1038/mi.2015.129

Chronic sleep deprivation impairs this clearance, promoting the accumulation of these neurotoxic substances, which are hallmarks of Alzheimers disease