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Common symptoms of cystic acne include: Large, pus-filled bumps Redness and swelling Pain or tenderness in the affected area Scarring once the bumps heal Cystic acne scars Cystic acne affects both the skin and the tissue underneath

The most commonly reported side effect in animal studies was mild local irritation at the injection site, which resolved without sequelae

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Sometimes this issue is fixed simply by optimizing buffers, for instance by increasing salt or detergent concentration, so that the interacting protein no longer binds to the GST only control, but still binds to your GST-fusion protein of interest