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IGF-1 LR3 sustains receptor occupancy for hours, which changes downstream gene-expression kinetics and raises distinct safety considerations discussed in the pharmacokinetics section below [4]

Adv Anat Pathol 16:365382 Murzaku EC, Penn LA, Hale CS et al (2014) Vulvar nevi, melanosis, and melanoma: an epidemiologic, clinical, and histopathologic review

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