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An experimental ghrelin vaccine, CYT009-GhrQb, was discontinued in 2006 as it did not have the expected effects on weight loss

Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist that was originally developed for type 2 diabetes management and subsequently approved by the FDA for chronic weight management under the brand name Wegovy

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They are most commonly used alongside primary weight loss medications like semaglutide or tirzepatide, but are also available as a standalone option

And dose adjustments are based on genuine biological response rather than storage artifacts