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In contrast to what is normally expected, oxygen consumption by tumor mitochondria was low when pyruvate (Pyr) was oxidized because citrate produced by citrate synthase (CS) was mainly exported to the cytosol to support the active cholesterol biosynthesis, thus, decreasing citrate availability to oxidation through the conventional KC flux

[DOI] [PMC free article] [PubMed] [Google Scholar] [79].Liu RM, Vayalil PK, Ballinger C, Dickinson DA, Huang WT, Wang S, et al

Association between glutathione S-transferase T1 null genotype and risk of myelodysplastic syndromes: A comprehensive meta-analysis

However, no significant differences were noted in muscle fiber size or fiber size distribution across groups, indicating that gross structural preservation was maintained regardless of treatment

Taken together, this data suggests that GCL only modestly regulates sensitivity to glucose deprivation