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How Tirzepatide Works Tirzepatide simultaneously activates two incretin hormone receptors: GLP-1 (Glucagon-Like Peptide-1): Reduces appetite, slows gastric emptying, and stimulates insulin secretion in a glucose-dependent manner

Key Points The insulin-like growth factor 1 ( IGF1 ) gene is a major target of growth hormone IGF1 binds the IGF1 receptor (IGF1R) with high affinity and the insulin receptor with low affinity

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These animals develop age-associated obesity caused by an induction of glycerol kinase and increased storage of TAG (53)

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