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Third, regulatory agencies should evaluate updates to prescribing information to reflect emerging safety signals meeting pharmacovigilance thresholds, while maintaining evidentiary standards for causal inference

Yet another small molecule that has been studied extensively as a highly potent small molecule inhibitor of both human and murine CD38 is 78c, which has been shown to be 10-fold less potent against the cyclase activity than the hydrolase activity of recombinant human CD38 139