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Collectively, these findings demonstrate that HMOX2-mediated haem degradation and MITOL-dependent ubiquitination at K68 of HMOX2 are critical for SDHB and Rieske stability, thereby sustaining mitochondrial respiration

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Moreover, the similar effective antitumor effects of DBG-mediated PCT were also observed on mouse liver cancer cells (H-22 cells) and mouse colon cells (CT26 cells) (Fig