glutathione reductase measurement of the Experimental Groups Glutathione reductase (GR) activity in

(2011PLoS ONE, 6 (3) DOI: 10.1371/journal.pone.0018046 40 Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Inducers of GlucuronidationInduction of UGTs, and other Phase II enzymes is usually modest, several fold, in contrast to possible induction noted for P450s.General inducers: PAH analogs, such as 3methylcholanthrene and naphthoflavone, are not very specific for UGT isozymes and also induce P450s.Phase II selective inducers are reported to activate the Antioxidant Response Element (ARE), e.g

Due to their major neuroprotective role, antioxidant therapy has increasingly been considered a promising approach for treating diseases involving neurodegeneration [149,154]

Ethics declarations Competing Interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

Transition of Thalassaemia and Friedreich ataxia from fatal to chronic diseases

Moreover, NRF2 regulates the expression of TGF-