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The risk of severe GI events is increased by the presence of the following factors: history of peptic ulcer disease or GI bleed, smoking, alcohol usage, concomitant usage of anticoagulants, or oral corticosteroids, older age, and poor general health status

Brand-name medications like Mounjaro and Zepbound are FDA-approved

Both adenosylcobalamin and hydroxycobalamin are generally considered highly safe and well-tolerated, as they are water-soluble vitamins and excess amounts are easily excreted in the urine

It provides a more stable, sustained presence of the peptide in the bloodstream rather than a rapid peak and fall, potentially allowing for a more prolonged therapeutic window

References 09738086 Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ, Handforth A, Faught E, Calabrese VP, Uthman BM, Ramsay RE, Mamdani MB