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doi: 10.1016/j.jneuroim.2019.04.011 219 ShahrokhiN.KhaksariM.NourizadS.ShahrokhiN.SoltaniZ.GholamhosseinianA

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Overall, scientific efforts over the past twenty years have shed light on the behavior of meningococcus within the host cell and have supported a model in which, after internalization by the host cell, the meningococcus is able to avoid lysosomal killing by cleaving LAMP1 through IgA protease, and to escape from the internalization vacuole through the C-terminal hemolytic domain of HrpA, reaching the cell cytosol

These glucocorticoid hormones, like cortisol, regulate the immune response by binding to an intracellular glucocorticoid receptor (GR) that is expressed in immune cells in lymphoid organs (126)

As shown in the complex structures of PL pro ubiquitin and PL pro ISG15, SUb1 of SARS-CoV-2 PL pro preferentially binds ISG15 through a different binding mode compared with uniquitin