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Following a 16 h incubation period, cells were harvested via centrifugation, washed twice using sterile PBS, and resuspended in PBS at a cell density of OD 600 = 1.0

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Alpha-lipoic acid, another antioxidant, has been shown to upregulate the SIRT1-dependent PGC-1 pathway, which is crucial for mitochondrial biogenesis and function

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Also known as Inonotus Obliquus (Mushroom) Extract, Chaga has antioxidant properties which means it can also help protect skin against oxidative stress that can lead to signs of aging like wrinkles

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