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For instance, oxidative stress can inhibit TGF- pathways, which are critical for producing extracellular matrix proteins such as aggrecan and type II collagen, necessary for disc hydration and structural integrity (Zheng et al., 2024)

10.1016/j.carpta.2023.100356 276 SalimS

Activation of these pathways regulates the expression of antioxidant enzymes and other antioxidants in cells, thereby reducing nerve cell damage caused by oxidative stress