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Anthocyanins also recycle glutathione thus sparing it if supplemented together (12)

Liu X, Lv Z, Zou J, Ma J, Wang J, Sa N, et al

Human MTHFR consists of an N-terminal catalytic domain (amino acids 1356) which binds 5,10-methylenetetrahydrofolate (5,10-methylene THF), and a C-terminal regulatory domain (amino acids 363656) which binds S-adenosylmethionine (AdoMet, SAM) 16,17