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Teixeira-Castro A, Ailion M, Jalles A, Brignull HR, Vilaca JL, Dias N, et al

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In a recent investigation undertaken by our group, adult mice with partial IGF-1 showed a decrease in the expression of genes involved in glucose metabolism (phosphoenolpyruvate carboxylase-1, glucose-6-phosphatase, pyruvate dehydrogenase kinase isoenzyme-4, and ATP-citrate lyase), resulting serious hyperglycaemia [164]

Labeling vials immediately after reconstitution prevents this scenario entirely

For general supplementation in at-risk groups (vegans, older adults), 25100 micrograms daily or 2000 micrograms weekly is typically sufficient