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In vitro assays confirmed their specific activity towards glutathione, with relevant kinetic parameters

Rapid endocytosis of copper-zinc superoxide dismutase into human endothelial cells: role for its vascular activity

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PAs are strongly supported to stabilize and protect membrane from toxic effects of metal ions specially the redox active metals (Sharma and Dietz, 2006)

Macrophages are the first to respond, triggering self-perpetuating inflammatory cycles that increase cytokine production and alter tissue structure (133)