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Its defining trait in the research literature is selectivity: unlike older GHRPs such as GHRP-6 or GHRP-2, ipamorelin is reported to release GH without meaningfully raising cortisol, prolactin, ACTH, or aldosterone, and with only minimal appetite stimulation

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When observing cellular uptake in controlled assays, scientists track how it selectively binds to the GHS-R1a receptor without triggering the release of adrenocorticotropic hormone (ACTH)

This objectively quantifies changes in visceral fat, subcutaneous fat, and lean mass, allowing researchers to evaluate whether the combination is producing the hypothesized benefits (preferential visceral fat loss with muscle preservation)

It does not simply suppress or stimulate