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Scenario 4: Elderly patient on multiple medications including metformin A 68-year-old with type 2 diabetes takes metformin, a proton pump inhibitor for reflux, and is starting semaglutide for additional glucose control and weight loss

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If you have a B12 deficiency, you can experience symptoms such as changes in mood, poor heart function, reduced fertility, and other negative effects

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The prolongation of apparent half-life with multiple dosing is characteristic of drugs that undergo distribution into deep tissue compartments from which elimination is slow, creating a multi-exponential elimination profile