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In vivo studies in Apc min/+ mice demonstrated that deoxycholic acid (DCA) promotes the adenoma-adenocarcinoma transition and DCAinduced changes to the microbial community promoted intestinal carcinogenesis (127, 128)

In conclusion, biologic therapeutics constitute an encouraging therapeutic evolution in managing lumbar disc degeneration, addressing core pathophysiology with potential to restore both mobility and functional capacity

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Western blotting Caco-2 cells were washed twice with PBS and subsequently lysed

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