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10.1186/s13023-018-0785-7 Orphanet J

Taken together, the development of chronic inflammatory processes may represent a pivotal component in the airway remodeling observed in individuals affected by both obesity and asthma

When volume is lost here through the progressive loss of subcutaneous fat, muscle and bone that characterises ageing in the face the effect radiates outward: the temples appear sunken and concave, the skin overlying the area becomes more thinly supported and shadowed, the tail of the brow loses its lateral support and descends, and the overall upper face takes on a hollowed, drawn and aged appearance

Therefore, the development of drugs that target common points of these crosstalk pathways is a novel approach to antagonize cisplatin-induced ototoxicity without affecting antineoplastic efficacy