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FIGURE 3 However, the limitation of passive targeting is that its targeting is relatively weak, and it is greatly affected by tumor heterogeneity and individual differences ( 2.2.2 Active targeting Active targeting, by contrast, modifies specific targeting molecules (such as antibodies, peptides, aptamers, etc.) on the surface of the nanocarriers so that they can accurately recognize and bind to specific antigens or receptors on the surface of tumor cells, thus achieving efficient drug delivery

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In recent years, research has primarily focused on TET-mediated active demethylation

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J.BirdD.BurlaB.DassaE.ForestierC.GeislerM.et al

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& Powell, A

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The imported cystine can then be converted to cysteine for the biosynthesis of glutathione and the maintenance of cellular redox homeostasis ( Since the net movement of amino acids into cells can only be mediated by uniporters and symporters ( SLC38A1 ) and SNAT2 ( SLC38A2 ) are uniporters ( SLC38A3 ) ( 0,+ (ATB 0,+ ), a symporter encoded by the SLC6A14 gene, can transport all neutral (including glutamine) and basic amino acids

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