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Those findings imply that while the reduced GSH levels in AS NPCs contribute to the elevated mROS, the aberrant m levels may derive from other AS mitochondria-related factors, such as structural aberrations and malfunction of the inner mitochondrial membrane or its respiratory complexes

Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig

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Site-specific pka determination of selenocysteine residues in selenovasopressin by using 77Se NMR spectroscopy

Glutathione is the body's master antioxidant, essential for cellular protection