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This in turn triggers the production of pro-inflammatory cytokines (TNF- and COX-2) and the elevation of oxidative stress markers ( Similarly, elevated levels of TNF- were also observed within the sciatic nerves and spinal cords of the STZ-induced DN group, and suppression of these proinflammatory cytokine levels was accompanied by mitigation of neuropathic pain ( p -NF-B

Typically, an initial follow-up with lab tests may be scheduled within the first one to three months of starting treatment