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Additional information Peer review information Nature Communications thanks Keith Blackwell and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Michael for helpful discussions, and members of the Virology Laboratory, the Structural Biology Section, the Structural Bioinformatics Core, and the Humoral Immunology Section, Vaccine Research Center, for discussions and comments on the manuscript

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By combining biomechanical analysis, anatomical screening, physiological conditioning, molecular biology, and personalized interventions, these approaches provide a holistic and effective strategy for reducing ACL injuries and optimizing athlete health and performance

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