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Elevated NO levels in the gut mucosa stimulate the production of pro-inflammatory cytokines like IL-17 by Th17 cells, forming a feedback loop that perpetuates inflammation

From a translational perspective, carnosine is an endogenous, non-toxic compound with a well-characterized safety profile and has already been investigated as a dietary supplement in clinical contexts (Swietach et al., 2024

Track moisturizer consumption as a proxy for barrier function

Results: The top metabolites discriminating MetALD from MASLD were Acetoacetate (OR:1.30, 95%1.21-1.41 p=1,48E-11), 3-Hydroxybutyrate (OR:1.29, 95%1.20-1.39 p=1,72E-11), Phospholipids in Large HDL (OR:1.20, 95%1.16-1.23 p=1,85E-32), Concentration of Large HDL Particles, Free Cholesterol in Large HDL, Cholesterol in Large HDL, Cholesteryl Esters in Large HDL, Total Lipids in Large HDL, Free, Cholesterol in Medium HDL, Cholesterol in Medium HDL

From target discovery to clinical drug development with human genetics