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Additionally, the COMPARE algorithm was used to evaluate the similarity of the biological response pattern of ZOT 5 -1-Me and ZOT 5 -1-Et with both FDA-approved drugs and chemotherapeutics undergoing combination clinical trials for GBM (Fig

Interestingly, we see marginal release of cytochrome c following 5FU and a transient dip in MOMP, but no enhanced difference in sensitivity to BH3-mimetics or increase in ATF4 expression or predicted activity in RNA-seq analysis (data not shown)

Estrogen deficiency and the decline of skin collagen were first observed in 1941 by Albright, who noticed that thin skin was more common in older women with osteoporotic fractures [21]

Supplementary information This file contains Supplementary Figs