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While standardized clinical assays are still needed, integrating mtDNA metrics into patient management holds promise for advancing personalized medicine in HIV care, shifting the focus from viral suppression to the optimization of metabolic and immunological health 7 Therapeutic strategies targeting mitochondria and mtDNA The recognition of mitochondrial dysfunction as a cornerstone of HIV pathogenesis and ART-related toxicity has catalyzed the search for therapeutic strategies aimed at preserving or restoring mitochondrial health

Conclusions Since the isolation of cortisone from the adrenal gland in 1934, steroid drugs have been the cornerstone of anti-inflammatory therapy, offering potent symptom control [317]

Glutathione supports antioxidant defenses, detoxification pathways, cellular protection, and overall cellular health.*

rxYFP: Redox-sensitive yellow fluorescent protein variants respond to changes in the thiol-disulfide equilibrium

Al-Sadeq, DW & Nasrallah, GK