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As such, interventions aimed to reduce SOD1 G93A expression and/or SOD1 G93A protein accumulation are most likely to achieve large rescuing effects in this model, whereas interventions that do not directly target the SOD1 G93A mechanisms are less likely to achieve success in retarding motor neuron disease of this model 23,24,25

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Lipids Health Dis 20 , 23 (2021)