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Description

Identification of a gain-of-function mutation in a golgi P-type ATPase that enhances Mn 2+ efflux and protects against toxicity

These results suggest the potential for the use of fungal GDHs in chemical industries

Excess manganese can overwhelm oxidative cellular antioxidant defense systems and inhibit mitochondrial function, which can result in cellular dysfunction and apoptosis of neurons (Brouillet et al., 1993