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This postmortem study helped confirm other studies indicating the importance of all three carotenoids in maintaining the structural integrity of the macula (Krinsky 2003)

Kirchgessner, T

Phosphorylated Smad2/3 complexes then translocate to the nucleus, where they induce transcription of fibrogenic genes, including collagen I/III, fibronectin, and -smooth muscle actin (-SMA)