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When used together, MTX and the added drugs can attack joint inflammation from multiple, complementary angles, producing a synergistic effect that is more powerful than either drug alone (Friedman & Cronstein, 2019)

Despite the potential of these novel therapies, the article acknowledges several limitations, including the variability in patient responses and the challenges of long-term adherence to treatment regimens

290 , L433L441 (2006)

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