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The authors acknowledge support from Canadian Institutes of Health Research (CIHR)

However, there is a observational study that propose the opposite conclusion (23)

The gap between doing it right and doing it wrong comes down to three things most handling guides never mention: pH stabilization, light protection, and cold chain maintenance from the moment the seal breaks

Interleukin 6-mediated endothelial barrier disturbances can be attenuated by blockade of the IL6 receptor expressed in brain microvascular endothelial cells