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Neurology 79 , 13921396 (2012)

81 XueY.LianW.ZhiJ.YangW.LiQ.GuoX.et al (2019)

These two effects then jointly lead to accumulation of cellular NO, ROS and lipid-ROS, and ultimately ferroptotic cell death

Genetic variants that impact the carboxyl-terminal domain of FTL and modify its iron-binding capacity have been linked to the disease hereditary neuroferritinopathy, it is characterized by progressive neurologic symptoms and iron accumulation, particularly in the basal ganglia