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However, it is well known that such retrospective observational epidemiological studies on drug effects may be influenced by two main limitations, protopathic bias (i.e., dermatologists were treating presumed psoriatic arthritisPsA) and confounding by indication (i.e., dermatologists tended to use more TNF inhibitors in suspected PsA compared to IL-12/23 inhibitors) [5]

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Second-line treatments, known as device-aided therapies (DATs), have been developed for LDRCs, such as continuous subcutaneous apomorphine infusion (CSAI), continuous subcutaneous foslevodopafoscarbidopa, infusion of levodopacarbidopa intestinal gel (LCIG entacapone) and subthalamic deep brain stimulation

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