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Medicines containing probenecid or sulfinpyrazone may prolong the excretion of diclofenac The absorption of vitamin b 12 in the gastrointestinal tract is reduced by the administration of the following drugs: aminoglycosides, colchicine, extended release potassium, aminosalicylic acid and its salt, anti-convulsive agent (phenytoin, phenobarbital and primodone), cobalt radiation in the small intestine and by excessive intake of alcohol for more than 2 weeks